Dr. Mark Jeremy Hunt received his PhD from the Dept. Pharmacology, University of Cambridge (Trinity College), researching Huntington's disease. Currently, he leads a research team at the Nencki Institute, Polish Academy of Sciences, researching the effects of ketamine on brain activity. The team publish results in international peer-reviewed journals and regularly present their latest findings at conferences. 

Selected publications

1.    Średniawa W, Wróbel J, Kublik E, Wójcik DK, Whittington MA, Hunt MJ. Network and synaptic mechanisms underlying high frequency oscillations in the rat and cat olfactory bulb under ketamine-xylazine anesthesia. Sci Rep. 2021 Mar18;11(1):6390. doi: 10.1038/s41598-021-85705-5.

2.    Jurkiewicz GJ, Hunt MJ, Żygierewicz J. Addressing Pitfalls in Phase-Amplitude Coupling Analysis with an Extended Modulation Index Toolbox. Neuroinformatics. 2021 Apr;19(2):319-345. doi: 10.1007/s12021-020-09487-3.

3.    Wróbel J, Średniawa W, Jurkiewicz G, Żygierewicz J, Wójcik DK, Whittington MA, Hunt MJ. Nasal respiration is necessary for ketamine-dependent high frequency network oscillations and behavioral hyperactivity in rats. Sci Rep. 2020 Nov 4;10(1):18981. doi: 10.1038/s41598-020-75641-1.

4.    Simon A, Yang M, Marrison JL, James AD, Hunt MJ, O'Toole PJ, Kaye PM, Whittington MA, Chawla S, Brackenbury WJ. Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo. J Neuroinflammation. 2020 Mar 19;17(1):87. doi: 10.1186/s12974-020-01753-0.

5.    Hunt MJ, Adams NE, Średniawa W, Wójcik DK, Simon A, Kasicki S, Whittington MA. The olfactory bulb is a source of high-frequency oscillations (130-180 Hz) associated with a subanesthetic dose of ketamine in rodents. Neuropsychopharmacology. 2019 Jan;44(2):435-442.

6.    Hunt MJ, Kopell NJ, Traub RD, Whittington MA. Aberrant Network Activity in Schizophrenia. Trends Neurosci. 2017 Jun;40(6):371-382.

7.    Hunt MJ, Olszewski M, Piasecka J, Whittington MA, Kasicki S. Effects of NMDA receptor antagonists and antipsychotics on high frequency oscillations recorded in the nucleus accumbens of freely moving mice. Psychopharmacology (Berl). 2015; 232(24):4525-35.

8.    Hall S, Hunt M, Simon A, Cunnington LG, Carracedo LM, Schofield IS, Forsyth R, Traub RD, Whittington MA. Unbalanced Peptidergic Inhibition in Superficial Neocortex Underlies Spike and Wave Seizure Activity. J Neurosci. 2015; 35(25):9302-14.

9.    Goda SA, Olszewski M, Piasecka J, Rejniak K, Whittington MA, Kasicki S, Hunt MJ. Aberrant high frequency oscillations recorded in the rat nucleus accumbens in the methylazoxymethanol acetate neurodevelopmental model of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2015; 3;61:44-51.

10.    Goda SA, Piasecka J, Olszewski M, Kasicki S, Hunt MJ. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl).  2013;228(2):271-82.

11.    Hunt MJ, Kasicki S. A systematic review of the effects of NMDA receptor antagonists on oscillatory activity recorded in vivo. J Psychopharmacol. 2013 Nov;27(11):972-86

12.    Olszewski M, Dolowa W, Matulewicz P, Kasicki S, Hunt MJ. NMDA receptor antagonist-enhanced high frequency oscillations: are they generated broadly or regionally specific? Eur Neuropsychopharmacol. 2013 Dec;23(12):1795-805.

13.    Olszewski M, Piasecka J, Goda SA, Kasicki S, Hunt MJ. Antipsychotic compounds differentially modulate high-frequency oscillations in the rat nucleus accumbens: a comparison of first- and second-generation drugs. Int J Neuropsychopharmacol. 2013 Jun;16(5):1009-20. 

14.    Nowak K, Meyza K, Nikolaev E, Hunt MJ, Kasicki S. Local blockade of NMDA receptors in the rat prefrontal cortex increases c-Fos expression in multiple subcortical regions.. Acta Neurobiol Exp (Wars). 2012;72(3):207-18.

15.    Hunt MJ, Falinska M, Łęski S, Wójcik DK, Kasicki S. Differential effects produced by ketamine on oscillatory activity recorded in the rat hippocampus, dorsal striatum and nucleus accumbens. J Psychopharmacol. (2011) 6:808-21.

16.    Matulewicz P, Kasicki S, Hunt MJ. The effect of dopamine receptor blockade in the rodent nucleus accumbens on local field potential oscillations and motor activity in response to ketamine. Brain Res. (2010) 1366; 226-232.

17.    Matulewicz P, Orzeł-Gryglewska J, Hunt MJ, Trojniar W, Jurkowlaniec E. Hippocampal theta rhythm after serotonergic activation of the pedunculopontine tegmental nucleus in anesthetized rats. Brain Res Bull. (2010) 83(5):257-61. 

18.    Hunt MJ, Falinska M, Kasicki S. Local injection of MK801 modifies oscillatory activity in the nucleus accumbens in awake rats. J Psychopharmacol. (2010) (6):931-41.

19.    Hunt MJ, Matulewicz P, Gottesmann C, Kasicki S. State-dependent changes in high-frequency oscillations recorded in the rat nucleus accumbens. Neuroscience. (2009) 164(2):380-6. 

20.    Hunt MJ, Garcia R, Large CH, Kasicki S. Modulation of high-frequency oscillations associated with NMDA receptor hypofunction in the rodent nucleus accumbens by lamotrigine. Prog Neuropsychopharmacol Biol Psychiatry. (2008) 32(5):1312-9.

21.    Hunt MJ, Raynaud B Garcia R. Ketamine induces high-frequency oscillations in the nucleus accumbens in freely moving rats. Biol Psychiatry. (2006) 60(11):1206-14.

22.    Hunt MJ, Kessal K, Garcia R. Ketamine induces dopamine-dependent depression of evoked hippocampal activity in the nucleus accumbens in freely moving rats. J Neurosci. (2005) 25(2):524-31.

23.    Morton AJ, Hunt MJ, Hodges AK, Lewis PD, Dunnett SB and Jones L. A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington’s disease. Eur J Neurosci. (2005)
21(4):855-70.

24.    Hunt MJ and Morton AJ. Atypical Diabetes Associated with Inclusion Formation in the R6/2 Mouse Model of Huntington’s Disease is not improved by treatment with hypoglycemic agents. Exptl Br. Res. (2005) 166(2):220-9.

25.    Hugues S, Kessal K, Hunt MJ, Garcia R. A conditioned stressful environment causes short-term metaplastic-like changes in the rat nucleus accumbens. J Neurophys. (2003) 90(5):3224-31.

26.    Cracowski JL, Marpeau C, Carpentier PH, Imbert B, Hunt M, Stanke-Labesque F, Bessard G. Enhanced in vivo lipid peroxidation in scleroderma spectrum disorders. Arthritis Rheum. 2001 May;44(5):1143-8.

27.    Cracowski JL, Stanke-Labesque F, Devillier P, Chavanon O, Hunt M, Souvignet C, Bessard G. Human internal mammary artery contraction by isoprostaglandin f(2alpha) type-III [8-iso-prostaglandin F(2alpha)]. Eur J Pharmacol. 2000 May 26;397(1):161-8.

28.    Gardan B, Cracowski JL, Sessa C, Hunt M, Stanke-Labesque F, Devillier P, Bessard G. Vasoconstrictor effects of iso-prostaglandin F2alpha type-III (8-iso-prostaglandin F2alpha) on human saphenous veins. J Cardiovasc Pharmacol. 2000 May;35(5):729-34

29.    Carter RJ, Hunt MJ, Morton AJ. Environmental stimulation increases survival in mice transgenic for exon 1 of the Huntington’s disease gene. Mov Disord. (2000) 15 (5): 925-37.

30.    Cracowski JL, Stanke-Labesque F, Sessa C, Hunt M, Chavanon O, Devillier P, Bessard G. Functional comparison of the human isolated femoral artery, internal mammary artery, gastroepiploic artery, and saphenous vein. Can J Physiol Pharmacol. 1999 Oct;77(10):770-6.

31.    Lione LA, Carter RJ, Hunt MJ, Bates GP, Morton AJ, Dunnett SB. Selective discrimination learning impairments in mice expressing the human Huntington’s disease mutation. J Neurosci. (1999) 23: 10428-37.


Other Publications

32.    Hunt MJ, Raflik K, Wesołowski D, Sakowska-Hunt DE “How to write a good abstract for a biomedical paper” March 2020 Medical Science Pulse 13(4):1-9 

33.    Hunt MJ, Ochmańska M, Cilulko-Dołęga J. How to write an effective response letter to reviewers. Medical Science Pulse. Jan/Mar 2019, 13(1):60-64. 

34.    Hunt MJ, Ochmańska M, Cilulko-Dołęga J. Scientific writing for the biomedical science. Medical Science Pulse Jan/Mar 2018, 12(1):29-33.